个人情况介绍、概览
现就职于沈阳药科大学制药工程学院有机化学教研室,主熟悉非专利药合成工艺研发流程,具有中试放大经验和CTD资料撰写经验,参与并完成多项校企合作项目如盐酸沙丙喋呤、盐酸莫西沙星、他克莫司、他唑巴坦、盐酸地匹福林、盐酸溴己新、拉洛他赛、伏诺拉生、左亚叶酸钠、米格列奈钙等原料药工艺的开发,以第一作者及通讯作者身份发表SCI论文多篇。
2019.09~至今,沈阳药科大学制药工程学院有机教研室讲师,药物化学系孙铁民教授课题组;
主要教育及工作经历:
2019.11~2022.07,沈阳药科大学/鲁南制药集团有限公司联合培养博士后,导师孙铁民(教授)、冯中(正高级工程师);
2015.09~2019.06,沈阳药科大学制药工程专业,博士,导师孙铁民(教授);
2012.09~2015.06,沈阳药科大学制药工程专业,硕士,导师孙铁民(教授);
2008.09~2012.06,山东师范大学化学化学与材料科学学院制药工程专业,学士。
论文
1.Transition-metal-free, one-pot synthesis of benzoxaboroles from o-bromobenzaldehydes via visible-light-promoted borylation.Organic & Biomolecular Chemistry.2021.共同通讯作者(1/2).(IF=3.89).中科院3区
2.Synthesis, crystal structure, DFT calculation and confirmation of absolute configuration of empagliflozin.Journal of Molecular Structure.2024.共同第一作者(1/2).(IF=3.8).中科院2区
3.Synthesis, crystal structure,anti-tuberculosis activity and toxicity prediction of N-(4-bromophenyl)-3-(5-(4-chloro-3-nitrophenyl)-1,3,4-oxadiazol-2-yl) benzenesulfonamide.Journal of Molecular Structure.2024.共同第一作者(1/2).(IF=3.8).中科院2区
4.Synthesis, single crystal culture, activation energy calculation and HMBC spectrum of 1-methyl-1,2,4-triazole-3-carboxylic acid methyl ester and its positional isomers.Journal of Molecular Structure.2024.共同通讯作者(1/2).(IF=4).中科院2区
5.Precise Preparation of a High-Purity Key Intermediate of Tazobactam.Organic Process Research & Development.2020.共同通讯作者(1/2).(IF=3.3).中科院3区
6.Crystal structure, DFT calculation, molecular docking, in vitro biological activity evaluation and in silico drug-likeness prediction of (E)-N-(4-bromophenyl)-4-(2-(2-hydroxybenzylidene) hydrazine-1-carbonyl) benzenesulfonamide.Journal of Molecular Structure.2023.共同第一作者(1/2).(IF=3.8).中科院2区
7.Exploring mRNA translation strategies for hypoxia adaptation across distantly related metazoans.Epigenomics.2023.共同通讯作者(1/2).(IF=3.8).中科院4区
8.Experimental crystal structure, conformational and spectroscopic studies of Allisartan Isoproxil accomplished with DFT calculations.Journal of Molecular Structure.2025.共同通讯作者(1/2).(IF=4.7).中科院2区
9.Synthesis, crystal structure, Hirshfeld surface analysis, molecular docking and DFT investigations of the anti-COVID-19 drug Ensitrelvir.Journal of Molecular Structure.2025.共同通讯作者(1/2).(IF=4.7).中科院2区