个人情况介绍、概览
本人并于2008年于沈阳药科大学获药物化学博士学位，毕业后留校任教。2009年4月至2012年6月入江苏康缘药业股份有限公司博士后工作站进行博士后研究。2016年10月至2017年4月赴日本武库川女子大学药学部进行学习交流。目前的主要研究方向为基于靶点的神经保护活性药物研究、基于活性的天然产物结构修饰与活性研究及化学生物学等。作为课题负责人主持了国家自然科学基金面上项目1项，国家自然科学基金青年基金项目1项，中国博士后科学基金1项，辽宁省科技厅项目1项，辽宁省教育厅项目1项，沈阳药科大学科研专项基金2项，另外，作为项目骨干成员参与国家自然科学基金面上项目3项。目前已在European Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry, Journal of Molecular Graphics and Modelling, Journal of Natural Medicines等期刊发表多篇科研论文。
论文
1.Computational investigation of the antagonism effect towards GluN2B-containing NMDA Receptor: combined Ligand-Based and Target-Based Approach.Journal of Molecular Graphics and Modelling.2019.(IF=2.097)
2.Design, synthesis and biological evaluation of 1-benzyl-5-oxopyrrolidine-2-carboximidamide derivatives as novel neuroprotective agents.European Journal of Medicinal Chemistry.2019.(IF=5.572)
3.Design, Synthesis and Biological Evaluation of Pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione Derivatives as Novel Neuroprotective Agents.Chemical Research in Chinese Universities.2020.(IF=1.063)
4.Design, synthesis and bioevaluation of 1,2,3,9-tetrahydropyrrolo [2,1-b]quinazoline-1-carboxylic acid derivatives as potent neuroprotective agents. .European Journal of Medicinal Chemistry.2018.(IF=4.833)
5.Pyrrolo[2,1-c][1,4]benzodiazepine-3,11-diones protect SHSY-5Y cells from Cd-induced apoptosis involving suppression of endoplasmic reticulum stress. .Bioorganic & Medicinal Chemistry.2018.(IF=2.802)
6.Simultaneous determination of three di-caffeoylquinic acids by UHPLC–MS/ MS in rat plasma and its application to a comparative pharmacokinetic study in normal and acute lung injury rat..Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences.2017.(IF=2.441)
7.Novel pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione (PBD) derivatives as selective HDAC6 inhibitors to suppress tumor metastasis and invasion in vitro and in vivo.Bioorganic Chemistry.2021.
8.Discovery of specific HDAC6 inhibitor with anti-metastatic effects in pancreatic cancer cells through virtual screening and biological evaluation..Bioorganic Chemistry.2020.
9.Design, Synthesis and Biological Evaluation of Pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione Derivatives as Novel Neuroprotective Agents.Chem. Res. Chinese Universities.2020.
10.Design, Synthesis and Biological Evaluation of Pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione Derivatives as Novel Neuroprotective Agents.Chemical. Res. Chinese Universities.2021.
