个人情况介绍、概览

侯状，男，博士，副教授。2012年毕业于沈阳药科大学，2017年于同校获药物化学博士学位。2019年被聘为沈阳药科大学副教授。作为课题负责人主持了国家自然科学基金青年基金项目1项、辽宁省科技厅项目1项、辽宁省教育厅项目2项、沈阳药科大学中青年发展支持计划1项；另外，作为项目骨干成员承担国家自然科学基金面上项目3项。目前已在Organic Letters., Eur. J. Med. Chem., J. Enzyme Inhibition and Med. Chem., Chin. J. Chem., Bioorg. Med. Chem.Lett.等期刊发表论文20余篇。

人才称号、社会兼职等

辽宁省“百千万人才工程”万人层次
沈阳市高层次人次

主要研究方向

研究方向一：基于靶点结构的抗青光眼、抗糖尿病及抗肿瘤药物研究
研究方向二：药物合成新工艺研究

纵向项目

1.基于糖基结构的新型碳酸酐酶II抑制剂设计、合成及抗青光眼活性评价，81903463，国家自然科学基金委员会。
2.新型碳酸酐酶II抑制剂设计、合成及抗青光眼活性评价，20180540032，辽宁省科学技术厅。
3.基于糖基结构的碳酸酐酶II抑制剂设计、合成及抗青光眼活性研究，2017LQN03，辽宁省教育厅。
4.基于靶点结构的碳酸酐酶IX抑制剂的设计、合成及抗肿瘤活性研究，LJKQZ2021036，辽宁省教育厅。

横向项目

无

论文

1.Design, synthesis and biological evaluation of carbohydrate-based sulfonamide derivatives as topical antiglaucoma agents through selective inhibition of carbonic anhydrase II.Journal of Enzyme Inhibition and Medicinal Chemistry.2020.(IF=4.673)
2.Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents.European Journal of Medicinal Chemistry.2020.(IF=5.572)
3.Discovery of novel artemisinin-sulfonamide hybrids as potential carbonic anhydrase IX inhibitors with improved antiproliferative activities.Bioorganic Chemistry.2020.(IF=4.831)
4.The Efficient Synthesis of Benzannulated Seven-Membered O‑Heterocycles via the Intramolecular Ring-Opening Cyclization of Cyclopropanes.Organic Letters.2019.(IF=6.091)
5.Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site.European Journal of Medicinal Chemistry.2017.(IF=4.816)
6.Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections.European Journal of Medicinal Chemistry.2021.(IF=6.514)
7.Design, synthesis, cytotoxicity and mechanism of novel dihydroartemisinin-coumarin hybrids as potential anti-cancer agents.European Journal of Medicinal Chemistry.2018.(IF=4.816)
8.Design, synthesis and biological evaluation of novel carbohydrate-based sulfonamide derivatives as antitumor agents.Bioorganic Chemistry.2020.(IF=4.831)
9.Novel carbohydrate-based sulfonamide derivatives as selective carbonic anhydrase II inhibitors: Synthesis, biological and molecular docking analysis.Bioorganic & Medicinal Chemistry Letters.2021.(IF=2.8)
10.Discovery of novel aminosaccharide-based sulfonamide derivatives as potential carbonic anhydrase II inhibitors.Bioorganic & Medicinal Chemistry Letters.2021.(IF=2.8)

学术成果

无