个人情况介绍、概览

侯状，男，博士，副教授。2012年毕业于沈阳药科大学，2017年于同校获药物化学博士学位。2019年被聘为沈阳药科大学副教授。作为课题负责人主持了国家自然科学基金青年基金项目1项、中国博士后科学基金面上项目1项、辽宁省科技厅项目2项、辽宁省教育厅项目3项、沈阳药科大学中青年发展支持计划1项、校企合作项目1项；另外，作为项目骨干成员承担国家自然科学基金面上项目4项。目前已在J. Med. Chem., Pharmacological Research., Organic Letters.等期刊发表论文30余篇。申请发明专利20余项，获授权专利10项。

人才称号、社会兼职等

辽宁省“兴辽英才”青年拔尖人才
辽宁省“百千万人才工程”万人层次
沈阳市高层次人次
本溪市高层次人才
沈阳药科大学“优青”
辽宁省药学会药物化学专业委员会委员
中国药物化学杂志青年编委

主要研究方向

研究方向一：基于靶点结构的抗青光眼、抗糖尿病、抗真菌及抗肿瘤药物研究
研究方向二：药物合成新工艺研究

纵向项目

无

论文

1.Design, synthesis and biological evaluation of carbohydrate-based sulfonamide derivatives as topical antiglaucoma agents through selective inhibition of carbonic anhydrase II.Journal of Enzyme Inhibition and Medicinal Chemistry.2020.(IF=4.673).中科院2区
2.Design, synthesis, and biological evaluation of novel miconazole analogues containing selenium as potent antifungal agents.European Journal of Medicinal Chemistry.2020.(IF=5.572).中科院2区
3.The Efficient Synthesis of Benzannulated Seven-Membered O‑Heterocycles via the Intramolecular Ring-Opening Cyclization of Cyclopropanes.Organic Letters.2019.(IF=6.091).中科院1区
4.Dual-tail approach to discovery of novel carbonic anhydrase IX inhibitors by simultaneously matching the hydrophobic and hydrophilic halves of the active site.European Journal of Medicinal Chemistry.2017.(IF=4.816)
5.Lead optimization generates selenium-containing miconazole CYP51 inhibitors with improved pharmacological profile for the treatment of fungal infections.European Journal of Medicinal Chemistry.2021.共同通讯作者（1/2）.(IF=6.514).中科院2区
6.Design, synthesis and biological evaluation of novel carbohydrate-based sulfonamide derivatives as antitumor agents.Bioorganic Chemistry.2020.(IF=4.831).中科院2区
7.Copper-Mediated Direct Trifluoromethylation of Trichloromethyl Alkanes.Organic Letters.2025.共同通讯作者（1/2）.(IF=5).中科院1区
8.Developing Novel Coumarin-Containing Azoles Antifungal Agents by the Scaffold Merging Strategy for Treating Azole-Resistant Candidiasis.Journal of Medicinal Chemistry.2023.通讯作者.(IF=6.8).中科院1区
9.Discovery of Novel α,β-unsaturated Amide Derivatives as Candidate Antifungals to Overcome Fungal Resistance.Journal of Medicinal Chemistry.2024.通讯作者.(IF=6.8).中科院1区
10.Discovery of novel selenium-containing azole derivatives as antifungal agents by exploiting the hydrophobic cleft of CYP51.European Journal of Medicinal Chemistry.2022.共同通讯作者（1/2）.中科院1区

学术成果

无